Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | F8 | P00451 | 1/20 | 0.37 |
| ▸ | F5 | P12259 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26984671 | 1.00 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2MEN1MAPT | |
| SCHEMBL30722006 | 0.81 | KDM1A (0.41) | CYP19A1CYP11B1CYP11B2S1PR5 | |
| SCHEMBL26984852 | 0.81 | KDM1A (0.41) | CYP19A1CYP11B1CYP11B2S1PR5 | |
| SCHEMBL20333011 | 0.79 | ALDH1A1 (0.38) | CYP19A1MEN1KMT2A | |
| SCHEMBL5346048 | 0.72 | CYP19A1 (0.62) | CYP19A1CYP11B1CYP11B2MEN1MAPT | |
| SCHEMBL29865065 | 0.72 | CYP19A1 (0.62) | CYP19A1CYP11B1CYP11B2MEN1MAPT | |
| SCHEMBL371744 | 0.72 | MEN1 (0.65) | CYP19A1CYP11B1CYP11B2MEN1MAPT | |
| SCHEMBL2419677 | 0.72 | MAPT (0.50) | CYP19A1CYP11B1CYP11B2MEN1MAPT | |
| SCHEMBL9388459 | 0.71 | MEN1 (0.58) | CYP19A1CYP11B1CYP11B2MEN1MAPT | |
| SCHEMBL9386456 | 0.70 | CYP19A1 (0.59) | CYP19A1CYP11B1CYP11B2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025151402-A1 | THIAZOLE TRPML1 AGONISTS AND USES THEREOF | LIBRA THERAPEUTICS, INC. (US) | 2025-07-17 | — | — | WO | disclosed |
| EP-4551571-A1 | OXAZOLE TRPML1 AGONISTS AND USES THEREOF | Libra Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| CN-119790050-A | Oxazole TRPML1 agonists and uses thereof | 利布拉医疗公司 | 2025-04-08 | — | — | CN | disclosed |
| WO-2024011155-A1 | OXAZOLE TRPML1 AGONISTS AND USES THEREOF | LIBRA THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |