SCHEMBL3072397

SCHEMBL3072397

c1ccc(-c2cn(-c3ccccn3)nn2)nc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 4/20 0.64
GSK3B P49841 1/20 0.64
MIF P14174 1/20 0.62
GRM5 P41594 2/20 0.54
KDM4E B2RXH2 4/20 0.50
LMNA P02545 3/20 0.50
CCR1 P32246 2/20 0.50
CCR5 P51681 2/20 0.50
CCR8 P51685 2/20 0.50
CYP1A2 P05177 1/20 0.50
POLB P06746 1/20 0.50
METAP1 P53582 1/20 0.50
BLM P54132 1/20 0.50
HIF1A Q16665 1/20 0.50
DOHH Q9BU89 1/20 0.50
P4HTM Q9NXG6 1/20 0.50
L3MBTL1 Q9Y468 4/20 0.48
TP53 P04637 4/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
NPC1 O15118 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5473306 0.84 FLT3 (0.48) FLT3GSK3BMIFGRM5GRM1
SCHEMBL31373412 0.84 FLT3 (0.66) FLT3GSK3BMIFGRM5KDM4E
SCHEMBL6953018 0.82 FLT3 (0.77) FLT3GSK3BMIFGRM5KDM4E
SCHEMBL17354058 0.81 FLT3 (0.55) FLT3GSK3BMIFGRM5KDM4E
SCHEMBL28464554 0.77 FLT3 (0.73) FLT3GSK3BMIFGRM5
SCHEMBL17980671 0.77 MIF (1.00) FLT3GSK3BMIFGRM5NPC1
SCHEMBL1674373 0.77 FLT3 (0.73) FLT3GSK3BMIFGRM5KDM4E
SCHEMBL29158520 0.77 FLT3 (1.00) FLT3GSK3BMIFGRM5KDM4E
SCHEMBL14416093 0.76 SMN1; SMN2 (0.50) FLT3GSK3BMIFGRM5KDM4E
SCHEMBL5203644 0.76 FLT3 (0.76) FLT3GSK3BMIFGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105218524-A \" one kettle way \" synthesizes the method that 3,5-bis-replaces-1,2,4-triazole compound UNIV HENAN POLYTECHNIC 2016-01-06 CN disclosed
US-7833331-B2 Non-toxic corrosion-protection pigments based on cobalt UNIVERSITY OF DAYTON (US) 2010-11-16 US disclosed
US-7789958-B2 Non-toxic corrosion-protection pigments based on manganese UNIVERSITY OF DAYTON (US) 2010-09-07 US disclosed
US-20090163628-A1 NON-TOXIC CORROSION-PROTECTION PIGMENTS BASED ON COBALT STURGILL JEFFREY ALLEN 2009-06-25 US disclosed
US-7537663-B2 Corrosion-inhibiting coating UNIVERSITY OF DAYTON (US) 2009-05-26 US disclosed
US-7422793-B2 Non-toxic corrosion-protection rinses and seals based on rare earth elements UNIVERSITY OF DAYTON (US) 2008-09-09 US disclosed
US-7407711-B2 Non-toxic corrosion-protection conversion coats based on rare earth elements UNIVERSITY OF DAYTON (US) 2008-08-05 US disclosed
US-7294211-B2 Non-toxic corrosion-protection conversion coats based on cobalt UNIVERSITY OF DAYTON (US) 2007-11-13 US disclosed
US-7291217-B2 Non-toxic corrosion-protection pigments based on rare earth elements UNIVERSITY OF DAYTON (US) 2007-11-06 US disclosed
US-20070149673-A1 NON-TOXIC CORROSION-PROTECTION PIGMENTS BASED ON MANGANESE STURGILL JEFFREY A 2007-06-28 US disclosed
US-20040011252-A1 Non-toxic corrosion-protection pigments based on manganese UNIVERSITY OF DAYTON 2004-01-22 US disclosed
US-20030234063-A1 Non-toxic corrosion-protection conversion coats based on cobalt DAYTON, UNIVERSITY OF 2003-12-25 US disclosed
US-20030230363-A1 Non-toxic corrosion-protection rinses and seals based on cobalt UNIVERSITY OF DAYTON 2003-12-18 US disclosed
WO-2003060192-A1 NON-TOXIC CORROSION-PROTECTION RINSES AND SEALS BASED ON COBALT UNIVERSITY OF DAYTON (US) 2003-07-24 WO disclosed
WO-2003060191-A2 NON-TOXIC CORROSION-PROTECTION CONVERSION COATINGES ABSED ON COBALT UNIVERSITY OF DAYTON (US) 2003-07-24 WO disclosed
WO-2003060019-A1 NON-TOXIC CORROSION PROTECTION PIGMENTS BASED ON COBALT UNIVERSITY OF DAYTON (US) 2003-07-24 WO disclosed
US-4104393-A ANTIASTHMA, ANTIALLERGY, ANTIGOUT, ANTIHYPERURICEMIA MERCK & CO., INC. (US) 1978-08-01 US disclosed
US-4048183-A ASTHMA, ALLERGY, GOUT, HYPERURICEMIA MERCK & CO., INC. (US) 1977-09-13 US disclosed
US-3984558-A 1,3,5-Trisubstituted-1,2,4-triazole compounds used as bronchodilators MERCK & CO., INC. (US) 1976-10-05 US disclosed
US-3978054-A ASTHMA, ANTIALLERGENS, GOUT MERCK & CO., INC. (US) 1976-08-31 US disclosed