Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | PDE9A | O76083 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179437 | 1.00 | RXRA (0.38) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL24179481 | 0.85 | RXRA (0.38) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL30724088 | 0.83 | CYP4F2 (0.35) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL24179522 | 0.82 | RET (0.31) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL30723767 | 0.82 | RET (0.31) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL24179540 | 0.80 | RXRA (0.34) | RXRARXRBRXRGCYP4F2CYP4A11 | |
| SCHEMBL24179546 | 0.79 | RXRA (0.44) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL25917461 | 0.78 | CYP4F2 (0.38) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL25918143 | 0.78 | RXRA (0.39) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL25918090 | 0.76 | RXRA (0.36) | RXRARXRBRXRGCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006776-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND MEDICAL USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |