SCHEMBL30728633

SCHEMBL30728633

NC(=O)c1ncccc1C(=O)O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.74
ALDH1A1 P00352 8/20 0.74
MAPT P10636 2/20 0.74
ALOX15 P16050 2/20 0.74
L3MBTL1 Q9Y468 2/20 0.74
CYP3A4 P08684 1/20 0.74
TSHR P16473 1/20 0.74
BLM P54132 1/20 0.74
AGER Q15109 1/20 0.74
NPSR1 Q6W5P4 1/20 0.74
NAPRT Q6XQN6 2/20 0.60
TDP1 Q9NUW8 1/20 0.59
LMNA P02545 2/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
PARP1 P09874 1/20 0.50
DHODH Q02127 1/20 0.47
MYC P01106 1/20 0.46
CYP1A2 P05177 1/20 0.46
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL939161 1.00 KDM4E (0.74) KDM4EALDH1A1MAPTALOX15L3MBTL1
Quinolinic Acid SCHEMBL27725715 0.88 KDM4E (0.88) KDM4EALDH1A1MAPTALOX15L3MBTL1
SCHEMBL31513532 0.88 PARP1 (0.58) KDM4EALDH1A1MAPTALOX15L3MBTL1
SCHEMBL773980 0.88 PARP1 (0.58) KDM4EALDH1A1MAPTALOX15L3MBTL1
Quinolinic Acid SCHEMBL69230 0.85 KDM4E (1.00) KDM4EALDH1A1MAPTALOX15L3MBTL1
Quinolinic Acid SCHEMBL29356188 0.85 KDM4E (1.00) KDM4EALDH1A1MAPTALOX15L3MBTL1
Quinolinic Acid SCHEMBL343618 0.85 KDM4E (1.00) KDM4EALDH1A1MAPTALOX15L3MBTL1
Quinolinic Acid SCHEMBL27676801 0.85 KDM4E (1.00) KDM4EALDH1A1MAPTALOX15L3MBTL1
SCHEMBL5158054 0.84 KDM4E (0.52) KDM4EALDH1A1MAPTALOX15L3MBTL1
SCHEMBL6333183 0.84 KDM4E (0.74) KDM4EALDH1A1MAPTALOX15L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114790167-B Preparation method of 2, 3-dichloropyridine 北京弗莱明科技有限公司 2024-01-05 CN disclosed