SCHEMBL30729426

SCHEMBL30729426

CC(=CCl)c1ccccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
ALDH1A1 P00352 4/20 0.46
POLB P06746 2/20 0.43
TSHR P16473 2/20 0.41
LMNA P02545 1/20 0.39
HPGD P15428 4/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 1/20 0.38
MAPT P10636 1/20 0.38
ERCC5 P28715 1/20 0.37
FEN1 P39748 1/20 0.37
PLAU P00749 1/20 0.37
ELANE P08246 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11216478 0.85 MEN1 (0.36) CES2CES1ALDH1A1POLBTSHR
SCHEMBL13767001 0.84 CES2 (0.50) CES2CES1ALDH1A1POLBTSHR
SCHEMBL2187631 0.80 CES2 (0.46) CES2CES1ALDH1A1POLBTSHR
SCHEMBL2187634 0.80 CES2 (0.46) CES2CES1ALDH1A1POLBTSHR
SCHEMBL27514145 0.80 CES2 (0.46) CES2CES1ALDH1A1POLBTSHR
SCHEMBL10433491 0.79 ALDH1A1 (0.35) ALDH1A1TSHRLMNAHPGDCYP1A2
SCHEMBL17448574 0.78 CES2 (0.45) CES2CES1ALDH1A1POLBTSHR
SCHEMBL16053233 0.78 CES2 (0.45) CES2CES1ALDH1A1POLBTSHR
SCHEMBL24579284 0.77 CES2 (0.43) CES2CES1ALDH1A1POLBTSHR
SCHEMBL7820881 0.77 ALDH1A1 (0.57) CES2CES1ALDH1A1POLBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117285453-A Method for synthesizing N-substituted-3-methylindole compound by catalyzing nitrogen heterocyclic carbene oxazoline ring palladium compound 南京林业大学 2023-12-26 CN disclosed