Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729921 | 0.85 | MAPK14 (0.40) | KDRBRAFALDH1A1MAPK14SMN1; SMN2 | |
| SCHEMBL27309768 | 0.85 | KDR (0.43) | KDRBRAFCACNA1HMAPK14ABL1 | |
| SCHEMBL27096935 | 0.85 | KDR (0.45) | KDRBRAFCACNA1HMAPK14EPHB6 | |
| SCHEMBL30729926 | 0.79 | MAPK14 (0.46) | KDRBRAFALDH1A1MAPK14NPC1 | |
| SCHEMBL27096813 | 0.78 | MAPK14 (0.41) | KDRBRAFMAPK14EPHB6RIPK2 | |
| SCHEMBL27309934 | 0.78 | KDR (0.41) | KDRBRAFMAPK14EPHB6RIPK2 | |
| SCHEMBL30729905 | 0.74 | MAPK14 (0.48) | KDRBRAFMAPK14 | |
| SCHEMBL27096991 | 0.73 | LRRK2 (0.39) | KDRBRAFCACNA1H | |
| SCHEMBL27309800 | 0.71 | MAPK14 (0.42) | KDRBRAFMAPK14ABL1MAPK13 | |
| SCHEMBL29834687 | 0.71 | MAPK14 (0.44) | KDRBRAFMAPK14NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026056-A2 | HETEROARYL COMPOUNDS AS EGFR INHIBITORS AND THEIR USES | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2024-02-01 | — | — | WO | disclosed |