Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729895 | 0.85 | KDR (0.40) | MAPK14KDRBRAFABL1ALDH1A1 | |
| SCHEMBL27096850 | 0.85 | MAPK14 (0.44) | MAPK14KDRBRAFABL1MAPK13 | |
| SCHEMBL27309979 | 0.85 | KDR (0.43) | MAPK14KDRBRAFABL1MAPK13 | |
| SCHEMBL30729926 | 0.79 | MAPK14 (0.46) | MAPK14KDRBRAFABL1KDM4E | |
| SCHEMBL27299379 | 0.75 | LRRK2 (0.43) | MAPK14KDRBRAFLRRK2 | |
| SCHEMBL27096891 | 0.75 | LRRK2 (0.43) | MAPK14LRRK2 | |
| SCHEMBL30729905 | 0.74 | MAPK14 (0.48) | MAPK14KDRBRAF | |
| SCHEMBL27299663 | 0.72 | LRRK2 (0.46) | MAPK14KDRBRAFLRRK2 | |
| SCHEMBL27309800 | 0.72 | MAPK14 (0.42) | MAPK14KDRBRAFABL1MAPK13 | |
| SCHEMBL27097010 | 0.72 | MAPK14 (0.43) | MAPK14KDRBRAFABL1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026056-A2 | HETEROARYL COMPOUNDS AS EGFR INHIBITORS AND THEIR USES | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2024-02-01 | — | — | WO | disclosed |