Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | IKZF2 | Q9UKS7 | 17/20 | 0.46 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29170731 | 0.87 | CRBN (0.45) | CRBNIKZF2IKZF1 | |
| SCHEMBL30121158 | 0.87 | CRBN (0.45) | CRBNIKZF2IKZF1 | |
| Hydrochloric Acid SCHEMBL29170744 | 0.82 | CRBN (0.52) | CRBNIKZF2IKZF1 | |
| Hydrochloric Acid SCHEMBL30121179 | 0.82 | CRBN (0.52) | CRBNIKZF2IKZF1 | |
| SCHEMBL20766670 | 0.81 | IKZF2 (0.65) | CRBNIKZF2IKZF1 | |
| SCHEMBL24319166 | 0.77 | CRBN (0.60) | CRBNIKZF2 | |
| SCHEMBL31347063 | 0.76 | CRBN (0.58) | CRBNIKZF2 | |
| SCHEMBL26107723 | 0.76 | CRBN (0.58) | CRBNIKZF2 | |
| SCHEMBL23173151 | 0.76 | CRBN (0.61) | CRBNIKZF2 | |
| SCHEMBL24745571 | 0.74 | CRBN (0.56) | CRBNIKZF2IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117396208-A | Small molecule degradants for cyclin dependent kinase 4/6 (CDK 4/6) and IKZF2 (HELIOS) and methods of use thereof | 达纳－法伯癌症研究所公司 | 2024-01-12 | — | — | CN | disclosed |