Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22554127 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1HTTCYP11B1CYP11B2 | |
| SCHEMBL22553760 | 0.86 | PRKAB2 (0.40) | NPC1CYP11B1CYP11B2CCNCCDK8 | |
| SCHEMBL30730822 | 0.86 | PRKAB2 (0.40) | NPC1CYP11B1CYP11B2CCNCCDK8 | |
| SCHEMBL22554087 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1HTTCYP11B1CYP11B2 | |
| SCHEMBL22554078 | 0.84 | NPC1 (0.39) | NPC1CCNCCDK8CD38TNIK | |
| SCHEMBL30730823 | 0.84 | NPC1 (0.39) | NPC1CCNCCDK8CD38TNIK | |
| SCHEMBL22553955 | 0.82 | PIM1 (0.42) | NPC1CYP11B2CCNCCDK8DGAT2 | |
| SCHEMBL22553920 | 0.80 | TNIK (0.40) | SMN1; SMN2NPC1CYP11B1CYP11B2CCNC | |
| SCHEMBL22553792 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1HTTCYP11B1CYP11B2 | |
| SCHEMBL30730803 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1HTTCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | claimed |
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |