Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22553792 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1HTTCYP11B2CYP11B1 | |
| SCHEMBL30730804 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1HTTCHEK1MAPT | |
| SCHEMBL22553865 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1HTTCHEK1MAPT | |
| SCHEMBL22553970 | 0.83 | CYP11B1 (0.41) | SMN1; SMN2NPC1HTTCYP11B2CYP11B1 | |
| SCHEMBL30730860 | 0.82 | PIP4K2A (0.46) | SMN1; SMN2NPC1HTTCYP11B2CYP11B1 | |
| SCHEMBL22553963 | 0.82 | PIP4K2A (0.46) | SMN1; SMN2NPC1HTTCYP11B2CYP11B1 | |
| SCHEMBL22554295 | 0.82 | BRD4 (0.48) | NPC1CCNCCDK8CHEK1PIP4K2A | |
| SCHEMBL22554254 | 0.81 | PRKAB2 (0.41) | NPC1CYP11B2CYP11B1CCNCCDK8 | |
| SCHEMBL22553817 | 0.81 | CYP11B2 (0.41) | SMN1; SMN2NPC1HTTCYP11B2CYP11B1 | |
| SCHEMBL30730784 | 0.81 | CYP11B2 (0.41) | SMN1; SMN2NPC1HTTCYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | claimed |
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |