SCHEMBL30731685

SCHEMBL30731685

COc1cc(C(C#N)c2ccccc2)ccc1O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
TSHR P16473 2/20 0.51
BLM P54132 2/20 0.51
NPSR1 Q6W5P4 1/20 0.51
KMT2A Q03164 2/20 0.51
BCHE P06276 2/20 0.50
TYR P14679 2/20 0.50
ACHE P22303 2/20 0.50
KDM4E B2RXH2 1/20 0.50
HSD17B10 Q99714 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CYP3A4 P08684 1/20 0.49
NFKB1 P19838 1/20 0.48
GAA P10253 3/20 0.47
MEN1 O00255 1/20 0.47
ALOX12 P18054 1/20 0.47
PMP22 Q01453 1/20 0.47
AKR1C3 P42330 1/20 0.46
AKR1C1 Q04828 1/20 0.46
PDE4D Q08499 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eugenol SCHEMBL9330421 0.81 TRPM8 (0.67) ALDH1A1KMT2AKDM4EL3MBTL1CYP3A4
SCHEMBL28767692 0.78 TSHR (0.57) TSHRBLMNPSR1BCHETYR
SCHEMBL77463 0.78 TSHR (0.58) ALDH1A1TSHRBLMNPSR1KMT2A
SCHEMBL85849 0.76 ALDH1A1 (0.56) ALDH1A1TSHRBLMNPSR1KMT2A
SCHEMBL5055339 0.75 ALDH1A1 (0.58) ALDH1A1NPSR1KMT2AGAAAKR1C3
SCHEMBL952648 0.74 CASR (0.48) ALDH1A1ACHEL3MBTL1GAAAKR1C3
SCHEMBL13198785 0.74 ALDH1A1 (0.58) ALDH1A1TSHRNPSR1L3MBTL1GAA
SCHEMBL10710548 0.74 IDO1 (0.50) ALDH1A1TSHRNPSR1KMT2AACHE
SCHEMBL20563424 0.73 TSHR (0.65) TSHRBLMNPSR1KMT2ABCHE
SCHEMBL1595549 0.73 TSHR (0.65) TSHRBLMNPSR1KMT2ABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117466771-A Green preparation method of alpha-aminonitrile 山东达因海洋生物制药股份有限公司 2024-01-30 CN disclosed