Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123579 | 1.00 | LTA4H (0.45) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL29123657 | 0.90 | SCN9A (0.39) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL30731741 | 0.90 | SCN9A (0.39) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL30731710 | 0.88 | LTA4H (0.44) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL29123425 | 0.88 | LTA4H (0.44) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL29123605 | 0.83 | LTA4H (0.52) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL29123608 | 0.83 | LTA4H (0.52) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL29123581 | 0.81 | SCN9A (0.44) | LTA4HMAPTSCN9AFPR2KCNH2 | |
| SCHEMBL30731757 | 0.80 | MAPT (0.38) | LTA4HMAPTSCN9ASMN1; SMN2SCN10A | |
| SCHEMBL30731769 | 0.79 | LTA4H (0.63) | LTA4HSCN9AFPR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117015537-A | Heteroaryl aminopropanol derivatives as inhibitors of LTA4H | 诺华股份有限公司 | 2023-11-07 | — | — | CN | disclosed |