Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | YWHAG | P61981 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081396 | 0.87 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL3089107 | 0.86 | MAPT (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL3078170 | 0.84 | MAPT (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL3087577 | 0.83 | HTT (0.66) | ALDH1A1SMN1; SMN2KDM4EMAPTCSF1R | |
| SCHEMBL3073387 | 0.80 | GAA (0.59) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL14336199 | 0.80 | HTT (0.48) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL8261932 | 0.77 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL29752319 | 0.77 | NPC1 (0.66) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL3088803 | 0.77 | NPC1 (0.66) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL14094757 | 0.77 | CSF1R (0.49) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429603-B2 | Such as 5-nitro-furan-2-carboxylic acid (2-piperidin-1-yl-phenyl)-amide; diabetes, angiogenesis, psoriasis, restenosis, schizophrenia, rheumatoid arthritis, cardiovascular disease, cancer | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2008-09-30 | — | — | US | claimed |
| US-20060094081-A1 | Crystal structure of the c-fms kinase domain: applications and use of heterologous substitutions of kinase insert domains for crystallization | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | US | claimed |
| WO-2006047505-A2 | CRYSTAL STRUCTURE OF THE C-FMS KINASE DOMAIN | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | claimed |
| EP-1631560-A2 | C-FMS KINASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-03-08 | — | — | EP | claimed |
| US-20050004112-A1 | C-fms kinase inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | claimed |
| WO-2004096795-A2 | C-FMS KINASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | claimed |
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-7790724-B2 | c-fms kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-07 | — | — | US | disclosed |
| EP-2016057-A1 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-21 | — | — | EP | disclosed |
| US-7429603-B2 | Such as 5-nitro-furan-2-carboxylic acid (2-piperidin-1-yl-phenyl)-amide; diabetes, angiogenesis, psoriasis, restenosis, schizophrenia, rheumatoid arthritis, cardiovascular disease, cancer | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2007123516-A1 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |
| US-20060258666-A1 | c-fms kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-16 | — | — | US | disclosed |
| US-20060094081-A1 | Crystal structure of the c-fms kinase domain: applications and use of heterologous substitutions of kinase insert domains for crystallization | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | US | disclosed |
| WO-2006047505-A2 | CRYSTAL STRUCTURE OF THE C-FMS KINASE DOMAIN | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-04 | — | — | WO | disclosed |
| EP-1631560-A2 | C-FMS KINASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-03-08 | — | — | EP | disclosed |
| US-20050004112-A1 | C-fms kinase inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | disclosed |
| WO-2004096795-A2 | C-FMS KINASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094081-A1 | Crystal structure of the c-fms kinase domain: applications and use of heterologous substitutions of kinase insert domains for crystallization | FLT3, FER, FES | ALDH1A1 4742/4885SMN1; SMN2 4729/4885KDM4E 3112/4885 |
| US-20060258666-A1 | c-fms kinase inhibitors | FLT3, FES, FER | ALDH1A1 4731/4885SMN1; SMN2 4235/4885KDM4E 1464/4885 |
| US-20050004112-A1 | C-fms kinase inhibitors | FLT3, FGR, FER | ALDH1A1 4574/4885SMN1; SMN2 4137/4885KDM4E 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.