Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26635018 | 0.87 | DDB1 (0.48) | CRBNDDB1CHRM2CHRM1CHRM4 | |
| SCHEMBL31003870 | 0.87 | DDB1 (0.45) | CRBNDDB1HRH3GPR119 | |
| SCHEMBL26851421 | 0.87 | DDB1 (0.45) | CRBNDDB1HRH3GPR119 | |
| SCHEMBL21998134 | 0.84 | CRBN (0.48) | CRBNDDB1CHRM2CHRM1CHRM4 | |
| SCHEMBL31003824 | 0.82 | CRBN (0.52) | CRBNDDB1HRH3 | |
| SCHEMBL26851507 | 0.82 | CRBN (0.52) | CRBNDDB1HRH3 | |
| SCHEMBL30225550 | 0.82 | CRBN (0.43) | CRBNDDB1CHRM2CHRM1CHRM4 | |
| SCHEMBL23541249 | 0.81 | DDB1 (0.49) | CRBNDDB1GPR119 | |
| SCHEMBL30893284 | 0.79 | DDB1 (0.50) | CRBNDDB1 | |
| SCHEMBL29612778 | 0.79 | CRBN (0.43) | CRBNDDB1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519273-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023215906-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | HANGZHOU JIJING PHARMACEUTICALTECHNOLOGY LIMITED (CN) | 2023-11-09 | — | — | WO | disclosed |