Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29612778 | 0.93 | CRBN (0.43) | CRBNDDB1HRH2HRH1MEN1 | |
| SCHEMBL23832693 | 0.88 | CRBN (0.48) | CRBNDDB1IRAK4IKZF3 | |
| SCHEMBL21997604 | 0.87 | DDB1 (0.45) | CRBNDDB1 | |
| SCHEMBL21998134 | 0.84 | CRBN (0.48) | CRBNDDB1HRH2HRH1MEN1 | |
| SCHEMBL21996871 | 0.83 | CRBN (0.51) | CRBNDDB1IKZF3 | |
| SCHEMBL26635141 | 0.83 | DDB1 (0.44) | CRBNDDB1 | |
| Hydrochloric Acid SCHEMBL21997496 | 0.83 | CRBN (0.50) | CRBNDDB1IKZF3 | |
| SCHEMBL31281986 | 0.82 | DDB1 (0.46) | CRBNDDB1IRAK4 | |
| SCHEMBL30733874 | 0.82 | CRBN (0.42) | CRBNDDB1CHRM2CHRM4CHRM5 | |
| SCHEMBL23807915 | 0.81 | CRBN (0.48) | CRBNDDB1IRAK4IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121043-A1 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |