Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29612778 | 0.84 | CRBN (0.43) | CRBNDDB1KMT2AMEN1POLB | |
| SCHEMBL30225550 | 0.84 | CRBN (0.43) | CRBNDDB1KMT2AMEN1POLB | |
| SCHEMBL21071066 | 0.84 | DDB1 (0.52) | CRBNDDB1KDM4E | |
| SCHEMBL30733874 | 0.84 | CRBN (0.42) | CRBNDDB1CHRM2CHRM4CHRM5 | |
| SCHEMBL21997875 | 0.83 | CRBN (0.45) | CRBNDDB1KMT2AMEN1 | |
| SCHEMBL21071248 | 0.83 | DDB1 (0.48) | CRBNDDB1 | |
| SCHEMBL26634850 | 0.81 | DDB1 (0.50) | CRBNDDB1ALDH1A1HPGD | |
| SCHEMBL31323754 | 0.81 | DDB1 (0.50) | CRBNDDB1ALDH1A1HPGD | |
| SCHEMBL31323706 | 0.81 | DDB1 (0.52) | CRBNDDB1 | |
| SCHEMBL24873004 | 0.81 | CRBN (0.63) | CRBNDDB1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886904-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020113233-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |