Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30734130 | 0.88 | ACHE (0.43) | IRAK4ACHEBACE1HTR1AHTR7 | |
| SCHEMBL30734203 | 0.84 | ACHE (0.56) | ACHEBACE1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL30734143 | 0.82 | IRAK4 (0.42) | IRAK4ACHEBACE1CYP1A2CYP3A4 | |
| SCHEMBL31745382 | 0.82 | ACHE (0.53) | ACHEBACE1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL30734149 | 0.81 | HTT (0.47) | IRAK4ACHEBACE1HTR1AHTR7 | |
| SCHEMBL30734175 | 0.81 | ACHE (0.44) | IRAK4ACHEBACE1HTR1AHTR7 | |
| SCHEMBL30734155 | 0.81 | ACHE (0.44) | IRAK4ACHEBACE1HTR1AHTR7 | |
| SCHEMBL30734144 | 0.80 | ACHE (0.45) | IRAK4ACHEBACE1CYP1A2CYP3A4 | |
| SCHEMBL30734174 | 0.80 | ACHE (0.45) | IRAK4ACHEBACE1CYP1A2CYP3A4 | |
| SCHEMBL30734169 | 0.74 | CYP3A4 (0.54) | CYP1A2CYP3A4ALDH1A1CLK4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250382301-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | UNIV ARIZONA (US) | 2025-12-18 | — | — | US | disclosed |
| EP-4543888-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | Arizona Board of Regents on behalf of The University of Arizona (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250083-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2023-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250382301-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | CLK2, CLK3, CLK1 | IRAK4 1207/4885ACHE 3704/4885BACE1 1412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.