Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.41 |
| ▸ | USP2 | O75604 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30734144 | 0.96 | ACHE (0.45) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL30734203 | 0.89 | ACHE (0.56) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL31745382 | 0.86 | ACHE (0.53) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL30734130 | 0.82 | ACHE (0.43) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL30734183 | 0.82 | HTT (0.51) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL30734138 | 0.80 | IRAK4 (0.46) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL30734200 | 0.78 | HTT (0.54) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL30734169 | 0.77 | CYP3A4 (0.54) | CYP3A4ALDH1A1HSD17B10CYP2D6MAPK1 | |
| SCHEMBL30734172 | 0.77 | ACHE (0.59) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL30734210 | 0.77 | ACHE (0.56) | ACHEBACE1CYP3A4ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543888-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | Arizona Board of Regents on behalf of The University of Arizona (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250083-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2023-12-28 | — | — | WO | disclosed |