Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29709511 | 0.74 | ASH1L (0.50) | ATRPIK3CDDHFRADORA2APIK3CB | |
| SCHEMBL1146451 | 0.73 | IMPDH2 (0.49) | ADORA2AFLT3PRKCQKDRIMPDH2 | |
| SCHEMBL7096071 | 0.73 | IMPDH2 (0.49) | PIK3CDADORA2APIK3CBPIK3CGASH1L | |
| SCHEMBL3073580 | 0.73 | PIK3CD (0.46) | PIK3CDDHFRPIK3CBPIK3CGPRKCQ | |
| SCHEMBL1807650 | 0.73 | MEN1 (0.66) | ATRPIK3CDDHFRPIK3CBKDM4E | |
| SCHEMBL3615777 | 0.71 | GSK3B (0.67) | PIK3CDGSK3BDYRK1ANFATC1PIM1 | |
| SCHEMBL25395833 | 0.71 | MPL (0.50) | ATRADORA2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL4945706 | 0.71 | IKBKB (0.52) | PIM1 | |
| SCHEMBL30309353 | 0.70 | IMPDH2 (0.57) | PIK3CDDYRK1AMAP2K1PRKCQPRKCD | |
| SCHEMBL403956 | 0.70 | IMPDH2 (0.57) | PIK3CDDYRK1AMAP2K1PRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K7 | ATR 535/4885PIK3CD 674/4885DHFR 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.