Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | AHR | P35869 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3304532 | 0.85 | PIK3CD (0.44) | IMPDH2IMPDH1PIK3CDAHRMAPK14 | |
| SCHEMBL30309353 | 0.83 | IMPDH2 (0.57) | IMPDH2IMPDH1PIK3CDAHRTRPA1 | |
| SCHEMBL403956 | 0.83 | IMPDH2 (0.57) | IMPDH2IMPDH1PIK3CDAHRTRPA1 | |
| SCHEMBL20540332 | 0.81 | PIK3CD (0.64) | PIK3CDAHRMAPK14ASH1LPIK3CB | |
| SCHEMBL3726444 | 0.81 | PRKCQ (0.46) | PIK3CDBRD4TRPA1PRKCQPRKCD | |
| SCHEMBL2358699 | 0.81 | IMPDH2 (0.65) | IMPDH2IMPDH1PRKCQPRKCD | |
| SCHEMBL30608285 | 0.81 | IMPDH2 (0.65) | IMPDH2IMPDH1PRKCQPRKCD | |
| SCHEMBL31264046 | 0.81 | IMPDH2 (0.65) | IMPDH2IMPDH1PRKCQPRKCD | |
| SCHEMBL3073580 | 0.76 | PIK3CD (0.46) | PIK3CDPIK3CBPRKCQPRKCDPIK3CG | |
| SCHEMBL29709559 | 0.76 | PIK3CD (0.44) | PIK3CDAHRMAPK14ASH1LPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |