Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16862950 | 0.76 | BRD4 (0.59) | BRD4CCNCCDK8ADRA1DPARP1 | |
| SCHEMBL30739134 | 0.76 | BRD4 (0.48) | BRD4CCNCCDK8ADRA1DPARP1 | |
| SCHEMBL9256717 | 0.72 | BRD4 (0.52) | BRD4CCNCCDK8ADRA1DPARP1 | |
| SCHEMBL30739179 | 0.71 | PARP1 (0.51) | BRD4ADRA1DL3MBTL1PARP1P2RX7 | |
| SCHEMBL31591086 | 0.66 | GRM2 (0.39) | ALDH1A1 | |
| SCHEMBL19924913 | 0.65 | BRD4 (1.00) | BRD4 | |
| SCHEMBL4734075 | 0.65 | BRD4 (0.57) | BRD4P2RX7ALDH1A1NOTUM | |
| SCHEMBL4024290 | 0.64 | SMN1; SMN2 (0.47) | BRD4L3MBTL1ALDH1A1NOTUM | |
| SCHEMBL6800202 | 0.63 | ADRA1D (0.41) | BRD4CCNCCDK8ADRA1DPARP1 | |
| SCHEMBL17166094 | 0.62 | TSHR (0.46) | BRD4ADRA1DL3MBTL1P2RX7NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |