Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4737901 | 0.92 | BRD4 (0.51) | BRD4NOTUMGAAPKMTSHR | |
| SCHEMBL2360506 | 0.89 | BRD4 (0.47) | BRD4P2RY14ALDH1A1 | |
| SCHEMBL4024290 | 0.89 | SMN1; SMN2 (0.47) | BRD4NOTUMGAAPKMTSHR | |
| SCHEMBL13363565 | 0.88 | BRD4 (0.46) | BRD4NOTUMGAARIPK1POLB | |
| SCHEMBL16862950 | 0.88 | BRD4 (0.59) | BRD4NOTUMRIPK1P2RX7MEN1 | |
| SCHEMBL6799177 | 0.86 | BRD4 (0.48) | BRD4MEN1KMT2A | |
| SCHEMBL17241086 | 0.85 | P2RX7 (0.46) | BRD4NOTUMPKMRIPK1P2RX7 | |
| SCHEMBL16862955 | 0.84 | ALDH1A1 (0.60) | GAATSHRP2RX7LMNAALDH1A1 | |
| SCHEMBL4419725 | 0.83 | BRD4 (0.67) | BRD4NOTUMGAAPKMTSHR | |
| SCHEMBL4737896 | 0.80 | BRD4 (0.41) | BRD4NOTUMRIPK1P2RX7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |