Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31591069 | 0.88 | KLKB1 (0.45) | HSD17B10KLKB1ALDH1A1KDM4ELMNA | |
| SCHEMBL30739230 | 0.85 | GRM2 (0.48) | HSD17B10KLKB1ALDH1A1KDM4ELMNA | |
| SCHEMBL1912400 | 0.82 | HSD17B10 (0.77) | HSD17B10L3MBTL1POLBTDP1KLKB1 | |
| SCHEMBL948453 | 0.81 | HSD17B10 (0.61) | HSD17B10L3MBTL1POLBTDP1KLKB1 | |
| SCHEMBL19299982 | 0.81 | HSD17B10 (0.65) | HSD17B10L3MBTL1POLBTDP1KLKB1 | |
| SCHEMBL16246805 | 0.80 | KLKB1 (0.62) | HSD17B10L3MBTL1POLBTDP1KLKB1 | |
| SCHEMBL553971 | 0.80 | HSD17B10 (0.63) | HSD17B10L3MBTL1POLBTDP1KLKB1 | |
| SCHEMBL18816489 | 0.80 | HSD17B10 (0.63) | HSD17B10L3MBTL1POLBTDP1KLKB1 | |
| SCHEMBL4019778 | 0.80 | HSD17B10 (0.72) | HSD17B10L3MBTL1POLBTDP1KLKB1 | |
| SCHEMBL553830 | 0.79 | L3MBTL1 (0.62) | HSD17B10L3MBTL1POLBTDP1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| CN-120051460-A | Plasma kallikrein inhibitors | 瑞泽路特有限公司 | 2025-05-27 | — | — | CN | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |