Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30739192 | 0.80 | CYP3A4 (0.51) | EGFRFGFR1BLKBTKJAK3 | |
| SCHEMBL30739291 | 0.80 | CYP3A4 (0.51) | EGFRFGFR1BLKBTKJAK3 | |
| SCHEMBL30739145 | 0.78 | TEK (0.37) | EGFRKDRFGFR1BLKBTK | |
| SCHEMBL30739237 | 0.76 | BLK (0.39) | EGFRFLT3BLKBTKITK | |
| SCHEMBL30739427 | 0.75 | BRD4 (0.42) | EGFRFLT3BLKBTKITK | |
| SCHEMBL30739288 | 0.74 | CYP3A4 (0.43) | EGFRFGFR1FLT3BTKERBB2 | |
| SCHEMBL30739376 | 0.74 | BRD4 (0.40) | EGFRFLT3BLKBTKITK | |
| SCHEMBL30739409 | 0.72 | CYP3A4 (0.42) | EGFRFGFR1BLKBTKITK | |
| SCHEMBL29178719 | 0.72 | BTK (0.50) | EGFRBLKBTKITKJAK2 | |
| SCHEMBL31213907 | 0.66 | EGFR (0.40) | EGFRKDRFGFR1BTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117466897-A | Highly selective FGFR2 inhibitors | 深圳福沃药业有限公司 | 2024-01-30 | — | — | CN | disclosed |