Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.73 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.72 |
| ▸ | KDR | P35968 | 10/20 | 0.72 |
| ▸ | CSF1R | P07333 | 4/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.72 |
| ▸ | TLK2 | Q86UE8 | 5/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057209 | 1.00 | PRKAA1 (0.73) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL13092040 | 0.93 | PRKAA1 (0.73) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL13092042 | 0.93 | PRKAA1 (0.73) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL13092039 | 0.93 | PRKAA1 (0.73) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL3051755 | 0.91 | PRKAA1 (0.71) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL13091976 | 0.91 | PRKAA1 (0.71) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL13101763 | 0.91 | PRKAA1 (0.76) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL3070262 | 0.91 | PRKAA1 (0.76) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL13091973 | 0.91 | PDGFRB (0.73) | PRKAA1PRKAA2PDGFRBKDRCSF1R | |
| SCHEMBL13091963 | 0.91 | PDGFRB (0.73) | PRKAA1PRKAA2PDGFRBKDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-21 | — | — | US | disclosed |
| EP-1893194-A4 | ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1893194-A1 | ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2008-03-05 | — | — | EP | disclosed |
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-12-21 | — | — | US | disclosed |
| WO-2006127961-A1 | ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | PHKG1, PHKG2, PRKCH | PRKAA1 5/4885PRKAA2 8/4885PDGFRB 388/4885 |
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | PHKG1, PHKG2, PRKCH | PRKAA1 6/4885PRKAA2 9/4885PDGFRB 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.