Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3074427 | 1.00 | MAPK1 (0.72) | MAPK1EGFRTP53MAPTNPC1 | |
| SCHEMBL2060824 | 0.84 | KMT2A (0.57) | MAPK1MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL7677592 | 0.84 | KMT2A (0.57) | MAPK1MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL25356392 | 0.84 | MAPK1 (1.00) | MAPK1TP53MAPTNPC1POLB | |
| SCHEMBL23251378 | 0.84 | MAPK1 (1.00) | MAPK1TP53MAPTNPC1POLB | |
| SCHEMBL25356142 | 0.84 | MAPK1 (0.68) | MAPK1EGFRTP53MAPTNPC1 | |
| SCHEMBL2060823 | 0.84 | KMT2A (0.57) | MAPK1MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL20504662 | 0.82 | MAPK1 (0.66) | MAPK1EGFRTP53MAPTNPC1 | |
| SCHEMBL20504663 | 0.82 | MAPK1 (0.66) | MAPK1EGFRTP53MAPTNPC1 | |
| SCHEMBL12529037 | 0.81 | MAPK1 (0.78) | MAPK1MAPTPOLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247442-A1 | Process for preparing isatins with control of side-product formation | WYETH (US) | 2006-11-02 | — | — | US | claimed |
| US-20100221445-A1 | O-DESMETHYLVENLAFAXINE AND BAZEDOXIFENE COMBINATION PRODUCT AND USES THEREOF | WYETH LLC (US) | 2010-09-02 | — | — | US | disclosed |
| US-20060247442-A1 | Process for preparing isatins with control of side-product formation | WYETH (US) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221445-A1 | O-DESMETHYLVENLAFAXINE AND BAZEDOXIFENE COMBINATION PRODUCT AND USES THEREOF | CYP19A1, HSD17B11, SLC6A4 | MAPK1 2967/4885EGFR 531/4885TP53 4833/4885 |
| US-20060247442-A1 | Process for preparing isatins with control of side-product formation | NISCH, HASPIN, INMT | MAPK1 4078/4885EGFR 3300/4885TP53 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.