Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL715228 | 0.89 | ALDH1A1 (0.35) | ALDH1A1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL914973 | 0.82 | KDM4E (0.36) | ALDH1A1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL916862 | 0.81 | BRD4 (0.37) | ALDH1A1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL917442 | 0.78 | BRD4 (0.35) | ALDH1A1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL917639 | 0.78 | MAPT (0.40) | ALDH1A1LMNANPSR1SMN1; SMN2PDE4A | |
| SCHEMBL917626 | 0.78 | KDM4E (0.35) | ALDH1A1LMNANPSR1HTTPDE4A | |
| SCHEMBL716247 | 0.77 | SLC6A4 (0.33) | ALDH1A1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL916278 | 0.77 | SLC6A4 (0.36) | ALDH1A1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL917635 | 0.77 | RECQL (0.40) | ALDH1A1LMNANPSR1SMN1; SMN2PDE4A | |
| SCHEMBL917572 | 0.77 | MEN1 (0.39) | ALDH1A1LMNANPSR1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795280-B2 | Indoles useful in the treatment of androgen-receptor related diseases | N.V. ORGANON (NL) | 2010-09-14 | — | — | US | disclosed |
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AKZO NOBEL N.V. (NL) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AR, NR5A1, SHBG | ALDH1A1 773/4885LMNA 3643/4885NPSR1 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.