SCHEMBL30745167

SCHEMBL30745167

CNC(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.70
LMNA P02545 1/20 0.70
KCNK3 O14649 3/20 0.53
KCNK9 Q9NPC2 3/20 0.53
PTGS1 P23219 1/20 0.53
RECQL P46063 1/20 0.51
F2R P25116 1/20 0.50
PPIA P62937 1/20 0.50
PLK1 P53350 1/20 0.50
PTPRC P08575 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
SCD O00767 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48
PDK2 Q15119 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1267035 1.00 GAA (0.70) GAALMNAKCNK3KCNK9PTGS1
SCHEMBL9830646 0.84 GAA (0.75) GAALMNAKCNK3KCNK9PTGS1
SCHEMBL9100658 0.84 CTSS (0.58) GAALMNAKCNK3KCNK9PTGS1
SCHEMBL8571125 0.84 CTSS (0.58) GAALMNAKCNK3KCNK9PTGS1
SCHEMBL8104116 0.82 GAA (0.55) GAALMNAPLK1PDK2
SCHEMBL3964208 0.82 LMNA (0.72) GAALMNAKCNK3KCNK9PTGS1
SCHEMBL2061662 0.82 GAA (0.49) GAALMNAKCNK3KCNK9PTGS1
SCHEMBL7984064 0.82 CTSS (0.63) GAALMNAPDK2
SCHEMBL15200725 0.81 LMNA (0.66) GAALMNAKCNK3KCNK9PTGS1
SCHEMBL27531979 0.81 LMNA (0.66) GAALMNAKCNK3KCNK9PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612134-A1 DIARYL DIAZOLE AND DIARYL TRIAZOLE DERIVATIVES FOR USE IN TREATING A DISEASE ASSOCIATED WITH KCNK13 ACTIVITY Cerevance, Inc. (US) 2025-09-10 EP disclosed
WO-2024095005-A1 DIARYL DIAZOLE AND DIARYL TRIAZOLE DERIVATIVES FOR USE IN TREATING A DISEASE ASSOCIATED WITH KCNK13 ACTIVITY Cerevance, Inc. (US) 2024-05-10 WO disclosed
CN-117510470-A Pyridazinone compounds and application thereof 暨南大学 2024-02-06 CN disclosed