Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 11/20 | 0.40 |
| ▸ | CCNC | P24863 | 10/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.38 |
| ▸ | SELE | P16581 | 5/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26985460 | 1.00 | CDK8 (0.40) | CDK8CCNCPTGS1PTGS2ICAM1 | |
| SCHEMBL30746484 | 0.84 | PTGS1 (0.40) | CDK8CCNCPTGS1PTGS2ICAM1 | |
| SCHEMBL26985737 | 0.84 | PTGS1 (0.40) | CDK8CCNCPTGS1PTGS2ICAM1 | |
| SCHEMBL26985080 | 0.73 | PTGS1 (0.45) | CDK8CCNCPTGS1PTGS2ICAM1 | |
| SCHEMBL28811745 | 0.72 | UCHL1 (0.34) | ICAM1SELEVCAM1UCHL1 | |
| SCHEMBL30746489 | 0.71 | HTT (0.38) | UCHL1 | |
| SCHEMBL26985465 | 0.71 | HTT (0.38) | UCHL1 | |
| SCHEMBL13727312 | 0.70 | LPL (0.33) | UCHL1 | |
| SCHEMBL20155354 | 0.69 | MAPT (0.44) | LIPE | |
| SCHEMBL365698 | 0.69 | TBXA2R (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4551558-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | Nested Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |