SCHEMBL30748700

SCHEMBL30748700

CC(=O)O[C@]1(C)C(=O)O[C@H]2[C@@H]3C(C)=CC[C@@H]3[C@@](C)(O)C[C@H](OC(=O)C=C(C)C)[C@H]21

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
MAPK1 P28482 1/20 0.46
HTT P42858 1/20 0.46
CYP19A1 P11511 1/20 0.38
JUN P05412 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cumambrin A SCHEMBL29770064 0.69 MAPT (0.56) GAAMAPTMAPK1HTTCYP19A1
SCHEMBL29627140 0.63 GAA (1.00) GAAMAPTMAPK1HTTCYP19A1
Cumambrin B SCHEMBL31055363 0.61 CYP19A1 (0.47) ALDH1A1GAAMAPTMAPK1HTT
SCHEMBL21632244 0.55 MAPT (0.47) ALDH1A1GAAMAPTMAPK1HTT
SCHEMBL21632245 0.55 MAPT (0.47) ALDH1A1GAAMAPTMAPK1HTT
SCHEMBL29774509 0.55 FNTA (0.47) GAAMAPTMAPK1HTT
SCHEMBL21563549 0.54 CYP19A1 (0.42) ALDH1A1GAAMAPTMAPK1HTT
SCHEMBL21563315 0.54 CYP19A1 (0.42) ALDH1A1GAAMAPTMAPK1HTT
SCHEMBL3182490 0.52 MAOA (0.30)
SCHEMBL31461645 0.51 CYP3A4 (0.44) ALDH1A1MAPTMAPK1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114276364-B Sesquiterpenoids in Artemisia mongolica, and preparation method and application thereof 中国科学院新疆理化技术研究所 2024-01-26 CN disclosed