SCHEMBL30748801

SCHEMBL30748801

C[C@@H]1CN(c2ccc(N3C(=O)C(C)(C)c4c(Cl)nc(Cl)nc43)cc2)C[C@H](C)O1

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.37
MAPT P10636 3/20 0.36
RAB9A P51151 2/20 0.36
TRPV1 Q8NER1 1/20 0.36
KMT2A Q03164 4/20 0.35
MAPK14 Q16539 1/20 0.35
PTH1R Q03431 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
SYK P43405 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
LRRK2 Q5S007 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
GAA P10253 1/20 0.32
FGFR1 P11362 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30748805 0.87 KMT2A (0.39) MAPTRAB9AKMT2AMAPK14SMN1; SMN2
SCHEMBL31691210 0.86 MAPK14 (0.35) MAPTRAB9ATRPV1KMT2AMAPK14
SCHEMBL30748931 0.86 PDE3B (0.41) RAB9AKMT2AMAPK14SMN1; SMN2NPC1
SCHEMBL30748732 0.82 TRPV1 (0.32) TRPV1PTH1RSYKLRRK2
SCHEMBL30749007 0.78 ELANE (0.44) ELANEKMT2AL3MBTL1TDP1ALDH1A1
SCHEMBL30749040 0.75 TRPV1 (0.38) MAPTRAB9ATRPV1SYKLRRK2
SCHEMBL30749132 0.75 RAB9A (0.41) MAPTRAB9AKMT2ASMN1; SMN2NPC1
SCHEMBL30748824 0.74 KMT2A (0.37) MAPTRAB9AKMT2AMAPK14SMN1; SMN2
SCHEMBL30748857 0.74 HRH3 (0.39) ELANEALDH1A1
SCHEMBL30748771 0.74 KMT2A (0.36) MAPTRAB9AKMT2AMAPK14SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT ELANE 7/4885MAPT 3029/4885RAB9A 2172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.