Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186628 | 0.99 | GRM5 (0.49) | GRM5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL301712 | 0.97 | GRM5 (0.52) | GRM5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2188728 | 0.97 | SPR (0.49) | GRM5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2246857 | 0.85 | MEN1 (0.65) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL3379160 | 0.84 | LMNA (0.49) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL303264 | 0.84 | LMNA (0.51) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL2209547 | 0.83 | LMNA (0.43) | GRM5KMT2ASPRALDH1A1HSD11B1 | |
| SCHEMBL2209550 | 0.82 | GRM5 (0.38) | GRM5MEN1KMT2ASPRHSD11B1 | |
| SCHEMBL302902 | 0.82 | LMNA (0.51) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL301955 | 0.82 | LMNA (0.49) | MEN1KMT2ALMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |