Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 8/20 | 0.32 |
| ▸ | TNKS | O95271 | 3/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30752833 | 0.84 | PRMT5 (0.46) | PARP1TNKSTNKS2PRMT5WDR77 | |
| SCHEMBL29915218 | 0.76 | POLB (0.46) | POLBPARP1PRMT5WDR77 | |
| SCHEMBL27002563 | 0.76 | POLB (0.46) | POLBPARP1PRMT5WDR77 | |
| SCHEMBL25581275 | 0.72 | ADORA1 (0.38) | POLBPARP1PRMT5WDR77 | |
| SCHEMBL25581278 | 0.71 | ADORA1 (0.33) | POLBPRMT5WDR77 | |
| SCHEMBL27002444 | 0.71 | AR (0.34) | POLBPARP1PRMT5WDR77 | |
| SCHEMBL30753085 | 0.69 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL27385996 | 0.69 | PRMT5 (0.48) | PARP1PRMT5WDR77 | |
| SCHEMBL25581297 | 0.69 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL25218581 | 0.68 | ADORA1 (0.31) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024027703-A1 | PRMT5 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海艾力斯医药科技股份有限公司 | 2024-02-08 | — | — | WO | disclosed |