Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 10/20 | 0.35 |
| ▸ | TNKS | O95271 | 3/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30752950 | 0.84 | POLB (0.34) | PRMT5WDR77PARP1TNKSTNKS2 | |
| SCHEMBL31496856 | 0.80 | PRMT5 (0.55) | PRMT5WDR77PARP1KMT2AMEN1 | |
| SCHEMBL29915065 | 0.78 | PRMT5 (0.61) | PRMT5WDR77PARP1KMT2A | |
| SCHEMBL27002364 | 0.78 | PRMT5 (0.61) | PRMT5WDR77PARP1KMT2A | |
| SCHEMBL23087658 | 0.76 | PRMT5 (0.64) | PRMT5WDR77PARP1KMT2AMEN1 | |
| SCHEMBL29735166 | 0.76 | PRMT5 (0.64) | PRMT5WDR77PARP1KMT2AMEN1 | |
| SCHEMBL30752949 | 0.72 | PRMT5 (0.53) | PRMT5WDR77PARP1KMT2A | |
| SCHEMBL31496822 | 0.72 | PRMT5 (0.53) | PRMT5WDR77PARP1KMT2A | |
| SCHEMBL31496831 | 0.72 | PRMT5 (0.60) | PRMT5WDR77PARP1 | |
| SCHEMBL23087513 | 0.71 | PRMT5 (0.67) | PRMT5WDR77PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024027703-A1 | PRMT5 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海艾力斯医药科技股份有限公司 | 2024-02-08 | — | — | WO | disclosed |