Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.55 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.55 |
| ▸ | UGT1A3 | P35503 | 1/20 | 0.55 |
| ▸ | UGT1A8 | Q9HAW9 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 3/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305411 | 0.84 | JUN (0.75) | JUNUGT1A1UGT1A3UGT1A8LTB4R | |
| SCHEMBL1100281 | 0.83 | JUN (0.64) | JUNUGT1A1UGT1A3UGT1A8HIF1A | |
| SCHEMBL27753402 | 0.80 | JUN (0.49) | JUNUGT1A1UGT1A3UGT1A8LMNA | |
| SCHEMBL6923825 | 0.79 | JUN (0.56) | JUNUGT1A1UGT1A3UGT1A8HIF1A | |
| SCHEMBL2964477 | 0.79 | JUN (0.59) | JUNUGT1A1UGT1A3UGT1A8LMNA | |
| SCHEMBL2967226 | 0.76 | JUN (0.69) | JUNUGT1A1UGT1A3UGT1A8LTB4R | |
| SCHEMBL668828 | 0.76 | JUN (0.57) | JUNUGT1A1UGT1A3UGT1A8LMNA | |
| SCHEMBL31484568 | 0.74 | MRGPRX4 (0.37) | PTGS1PTGS2MAOB | |
| SCHEMBL2965022 | 0.74 | JUN (0.61) | JUNUGT1A1UGT1A3UGT1A8PDE4A | |
| SCHEMBL2967854 | 0.73 | JUN (0.59) | JUNUGT1A1UGT1A3UGT1A8LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240366544-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | UNIV JOHNS HOPKINS (US) | 2024-11-07 | — | — | US | claimed |
| WO-2024026354-A2 | METHODS AND COMPOSITIONS FOR USE IN TREATING AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE (ARPKD) | THE GENERAL HOSPITAL CORPORATION (US) | 2024-02-01 | — | — | WO | disclosed |