Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CASP3 | P42574 | 3/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688703 | 1.00 | MEN1 (0.51) | MEN1KMT2ACASP3AVPR1AATM | |
| SCHEMBL13967321 | 0.87 | RAB9A (0.42) | MEN1KMT2ACASP3HTTRXFP1 | |
| SCHEMBL9919073 | 0.82 | CASP3 (0.54) | MEN1KMT2ACASP3AVPR1AATM | |
| SCHEMBL31240990 | 0.81 | CACNA2D1 (0.47) | MEN1KMT2ACASP3AVPR1AATM | |
| SCHEMBL5712376 | 0.81 | SMN1; SMN2 (0.40) | MEN1KMT2AHTTRXFP1MAPT | |
| SCHEMBL3820085 | 0.78 | USP2 (0.47) | MEN1KMT2ACASP3ATMHTT | |
| SCHEMBL4207211 | 0.78 | PDE7A (0.58) | MEN1KMT2ACASP3AVPR1AATM | |
| SCHEMBL3821246 | 0.77 | CASP3 (0.46) | MEN1KMT2ACASP3AVPR1AATM | |
| SCHEMBL9954421 | 0.77 | MEN1 (0.51) | MEN1KMT2AAVPR1AATMRXFP1 | |
| SCHEMBL17674019 | 0.76 | SMN1; SMN2 (0.58) | MEN1KMT2ACASP3HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4526304-A1 | INHIBITORS OF PARG | 858 Therapeutics, Inc. (US) | 2025-03-26 | — | — | EP | disclosed |
| WO-2023224998-A1 | INHIBITORS OF PARG | 858 THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |