Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | RRM1 | P23921 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688901 | 1.00 | TSHR (0.34) | TSHRSMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL5524015 | 0.88 | TSHR (0.37) | TSHRSMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL5521626 | 0.87 | MEN1 (0.36) | TSHRSMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL26688793 | 0.87 | MAPT (0.33) | TSHRSMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL30757348 | 0.87 | MAPT (0.33) | TSHRSMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL26688799 | 0.85 | MAPT (0.33) | ALDH1A1POLBMAPTEDNRA | |
| SCHEMBL30757516 | 0.85 | MAPT (0.33) | ALDH1A1POLBMAPTEDNRA | |
| SCHEMBL26688914 | 0.80 | MAPT (0.33) | ALDH1A1POLBMAPT | |
| SCHEMBL30757411 | 0.80 | MAPT (0.33) | ALDH1A1POLBMAPT | |
| SCHEMBL30171242 | 0.80 | EDNRA (0.38) | TSHRSMN1; SMN2CYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |