Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688799 | 1.00 | MAPT (0.33) | MAPTTP53RXFP1PDE5AEDNRA | |
| SCHEMBL26688914 | 0.93 | MAPT (0.33) | MAPTTP53RXFP1PDE5AALDH1A1 | |
| SCHEMBL30757411 | 0.93 | MAPT (0.33) | MAPTTP53RXFP1PDE5AALDH1A1 | |
| SCHEMBL30757348 | 0.92 | MAPT (0.33) | MAPTTP53RXFP1PDE5AALDH1A1 | |
| SCHEMBL26688793 | 0.92 | MAPT (0.33) | MAPTTP53RXFP1PDE5AALDH1A1 | |
| SCHEMBL5534772 | 0.87 | EDNRA (0.35) | MAPTTP53EDNRAAGTR1 | |
| SCHEMBL5528962 | 0.87 | GAA (0.32) | MAPTEDNRAAGTR1ALDH1A1 | |
| SCHEMBL5530422 | 0.86 | EDNRA (0.38) | EDNRAAGTR1 | |
| SCHEMBL30757386 | 0.85 | TSHR (0.34) | MAPTEDNRAALDH1A1POLB | |
| SCHEMBL26688901 | 0.85 | TSHR (0.34) | MAPTEDNRAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |