Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20540355 | 0.78 | SMN1; SMN2 (0.54) | TSHRSMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL10617379 | 0.77 | PTGS1 (0.47) | TSHRSMN1; SMN2ALDH1A1HPGDPTGS1 | |
| SCHEMBL8997373 | 0.74 | POLB (0.39) | SMN1; SMN2ALDH1A1TP53HPGDCYP1A2 | |
| SCHEMBL12629794 | 0.74 | RAB9A (0.51) | SMN1; SMN2RAB9AMEN1KMT2AMAPK10 | |
| SCHEMBL11094611 | 0.74 | PTGS1 (0.42) | TSHRSMN1; SMN2ALDH1A1PTGS1PTGS2 | |
| SCHEMBL10618486 | 0.74 | PTGS1 (0.46) | TSHRSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL10617044 | 0.73 | PTGS1 (0.46) | TSHRSMN1; SMN2PTGS1PTGS2RAB9A | |
| SCHEMBL10618027 | 0.73 | PTGS1 (0.46) | TSHRSMN1; SMN2PTGS1PTGS2RAB9A | |
| SCHEMBL8997213 | 0.72 | GFER (0.64) | TSHRALDH1A1PTGS1PTGS2GFER | |
| SCHEMBL8997219 | 0.71 | PTGS1 (0.58) | TSHRSMN1; SMN2ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |