Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 2/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19063606 | 0.88 | KDM4E (0.53) | ABCB1ITGB3ITGA2BGPR119KEAP1 | |
| SCHEMBL30990345 | 0.88 | KDM4E (0.53) | ABCB1ITGB3ITGA2BGPR119KEAP1 | |
| SCHEMBL24392263 | 0.87 | NAMPT (0.51) | MEN1KMT2AABCB1KLK7KLK5 | |
| SCHEMBL28512955 | 0.85 | ABCB1 (0.46) | MEN1KMT2ANPSR1ABCB1KLK7 | |
| SCHEMBL28505326 | 0.85 | ABCB1 (0.46) | MEN1KMT2ANPSR1ABCB1KLK7 | |
| SCHEMBL20782479 | 0.84 | KDM4E (0.58) | ITGB3ITGA2BGPR119KEAP1NFE2L2 | |
| SCHEMBL17157131 | 0.83 | MEN1 (0.49) | MEN1KMT2ANPSR1GPR119SYK | |
| SCHEMBL21248918 | 0.81 | ABCB1 (0.53) | ABCB1KLK7KLK5MAPTITGB3 | |
| SCHEMBL20660097 | 0.81 | KDM4E (0.54) | MEN1KMT2AITGB3ITGA2BGPR119 | |
| SCHEMBL31251088 | 0.80 | GPR119 (0.51) | MEN1KMT2AABCB1GPR119KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4573095-A1 | PYRIDOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| WO-2024040131-A1 | PYRIDOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-02-22 | — | — | WO | disclosed |