Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27041499 | 1.00 | MDM2 (0.38) | MDM2ALDH1A1HPGDDUSP3PTPN5 | |
| SCHEMBL27041496 | 1.00 | MDM2 (0.38) | MDM2ALDH1A1HPGDDUSP3PTPN5 | |
| SCHEMBL31754318 | 0.93 | SCN9A (0.39) | MDM2ALDH1A1HPGDDUSP3PTPN5 | |
| SCHEMBL30759380 | 0.93 | SCN9A (0.39) | MDM2ALDH1A1HPGDDUSP3PTPN5 | |
| SCHEMBL27041572 | 0.89 | PTPN1 (0.32) | MDM2ALDH1A1HPGDDUSP3PTPN5 | |
| SCHEMBL27041547 | 0.89 | PTPN1 (0.32) | MDM2ALDH1A1HPGDDUSP3PTPN5 | |
| SCHEMBL30759426 | 0.85 | SCN9A (0.34) | MDM2SCN9ACTSLCTSB | |
| SCHEMBL27041569 | 0.81 | TLR2 (0.49) | MDM2TLR2CTSLCTSB | |
| SCHEMBL27041543 | 0.81 | TLR2 (0.49) | MDM2TLR2CTSLCTSB | |
| SCHEMBL27041476 | 0.80 | TBXAS1 (0.44) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558513-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | Merck Sharp & Dohme LLC (US) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024020159-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2024-01-25 | — | — | WO | disclosed |