Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PRKCG | P05129 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30760076 | 0.78 | MAPK1 (0.60) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL27360361 | 0.78 | MAPK1 (0.38) | MAPK1 | |
| SCHEMBL30760039 | 0.77 | MAPK1 (0.46) | MAPK1ABL1ROCK2ROCK1RPS6KA5 | |
| SCHEMBL30760172 | 0.74 | CYP1A2 (0.47) | MAPK1CYP3A4 | |
| SCHEMBL30760038 | 0.74 | VHL (0.51) | MAPK1 | |
| SCHEMBL3104408 | 0.73 | MAPK1 (0.67) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL27360587 | 0.72 | PTGES (0.35) | MAPK1ABL1CCR5KCNH2BRAF | |
| SCHEMBL30760184 | 0.72 | MAPK1 (0.51) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL27360367 | 0.71 | XIAP (0.38) | ABL1PTGESPTGS2 | |
| SCHEMBL27360586 | 0.71 | DPP4 (0.40) | MAPK1ABL1CCR5KCNH2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024040080-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2024-02-22 | — | — | WO | disclosed |