Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30760064 | 0.85 | MKNK1 (0.45) | AAK1CYP17A1RIPK1PTPRBROCK2 | |
| SCHEMBL30760051 | 0.83 | TRPV1 (0.45) | AAK1RIPK1ROCK2ROCK1MAPK13 | |
| SCHEMBL30760154 | 0.82 | ROCK2 (0.43) | AAK1CYP17A1RIPK1PTPRBROCK2 | |
| SCHEMBL30760073 | 0.81 | HDAC4 (0.40) | AAK1CYP17A1PTPRBROCK2ROCK1 | |
| SCHEMBL28995700 | 0.80 | PPARG (0.45) | RIPK1MEN1ALDH1A1LMNAHPGD | |
| SCHEMBL17619268 | 0.80 | PPARG (0.45) | RIPK1MEN1ALDH1A1LMNAHPGD | |
| SCHEMBL19580931 | 0.80 | VHL (0.46) | PTPRB | |
| SCHEMBL30759976 | 0.80 | HDAC4 (0.45) | AAK1CYP17A1RIPK1PTPRBROCK2 | |
| SCHEMBL18551023 | 0.80 | VHL (0.46) | PTPRB | |
| SCHEMBL14831426 | 0.79 | CTSK (0.52) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024040080-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2024-02-22 | — | — | WO | disclosed |