Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2387673 | 0.91 | PRMT5 (0.47) | LIPGJAK2JAK1PRMT5WDR77 | |
| SCHEMBL28959331 | 0.84 | L3MBTL1 (0.50) | LIPGJAK2JAK1PRMT5WDR77 | |
| SCHEMBL20129209 | 0.84 | L3MBTL1 (0.47) | LIPGJAK2JAK1PRMT5WDR77 | |
| SCHEMBL20132906 | 0.84 | L3MBTL1 (0.47) | LIPGJAK2JAK1PRMT5WDR77 | |
| SCHEMBL22906672 | 0.83 | L3MBTL1 (0.51) | JAK2JAK1PRMT5WDR77STS | |
| SCHEMBL21458596 | 0.82 | STS (0.53) | LIPGJAK2JAK1PRMT5WDR77 | |
| SCHEMBL31618610 | 0.82 | PRMT5 (0.49) | LIPGJAK2JAK1PRMT5WDR77 | |
| SCHEMBL27098607 | 0.82 | JAK2 (0.44) | LIPGJAK2JAK1STSL3MBTL1 | |
| SCHEMBL22906856 | 0.81 | STS (0.52) | LIPGJAK2JAK1PRMT5WDR77 | |
| SCHEMBL21458929 | 0.81 | STS (0.52) | LIPGJAK2JAK1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568946-A1 | MACROCYCLIC BCL6 DEGRADERS | Dana-Farber Cancer Institute, Inc. (US) | 2025-06-18 | — | — | EP | disclosed |
| CN-119585240-A | Macrocyclic BCL6 degrading agents | 丹娜-法伯癌症研究院 | 2025-03-07 | — | — | CN | disclosed |
| WO-2024035688-A1 | MACROCYCLIC BCL6 DEGRADERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-02-15 | — | — | WO | disclosed |