Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260809 | 0.91 | IRAK4 (0.38) | NPSR1IRAK1IRAK4MAP3K7TAB1 | |
| SCHEMBL30765283 | 0.91 | IRAK4 (0.38) | NPSR1IRAK1IRAK4MAP3K7TAB1 | |
| SCHEMBL30765309 | 0.88 | ACVR1 (0.41) | NPSR1CCNA2CDK2IRAK4ALDH1A1 | |
| SCHEMBL27260718 | 0.88 | ACVR1 (0.41) | NPSR1CCNA2CDK2IRAK4ALDH1A1 | |
| SCHEMBL27260725 | 0.84 | KCNH2 (0.40) | IRAK1IRAK4MAP3K7TAB1BRD4 | |
| SCHEMBL30765350 | 0.84 | PIK3CD (0.41) | NPSR1CCNA2CDK2IRAK1IRAK4 | |
| SCHEMBL27260617 | 0.84 | KCNH2 (0.47) | MAP3K7TAB1BRD4 | |
| SCHEMBL30765338 | 0.83 | RET (0.45) | IRAK1 | |
| SCHEMBL724751 | 0.80 | MAP3K7 (0.47) | IRAK1MAP3K7TAB1BRD4 | |
| SCHEMBL27260728 | 0.79 | BRD4 (0.49) | SYKIRAK1IRAK4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |