Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 8/20 | 0.40 |
| ▸ | F13A1 | P00488 | 6/20 | 0.40 |
| ▸ | TGM1 | P22735 | 4/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765265 | 0.83 | SYK (0.42) | IRAK1 | |
| SCHEMBL27260718 | 0.83 | ACVR1 (0.41) | RET | |
| SCHEMBL30765309 | 0.83 | ACVR1 (0.41) | RET | |
| SCHEMBL27260809 | 0.81 | IRAK4 (0.38) | IRAK1 | |
| SCHEMBL30765283 | 0.81 | IRAK4 (0.38) | IRAK1 | |
| SCHEMBL30765350 | 0.80 | PIK3CD (0.41) | IRAK1 | |
| SCHEMBL27260617 | 0.79 | KCNH2 (0.47) | LRRK2MET | |
| SCHEMBL30765299 | 0.79 | IRAK1 (0.41) | RETIRAK1PIK3CATGFBR1 | |
| SCHEMBL30765282 | 0.76 | PIK3CG (0.49) | PIK3CA | |
| SCHEMBL27260725 | 0.76 | KCNH2 (0.40) | IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |