Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 6/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260809 | 1.00 | IRAK4 (0.38) | IRAK4LMNAGAAHPGDHSD17B10 | |
| SCHEMBL30765265 | 0.91 | SYK (0.42) | IRAK4LMNAGAAHPGDHSD17B10 | |
| SCHEMBL30765309 | 0.86 | ACVR1 (0.41) | IRAK4LMNAGAAALDH1A1BRD4 | |
| SCHEMBL27260718 | 0.86 | ACVR1 (0.41) | IRAK4LMNAGAAALDH1A1BRD4 | |
| SCHEMBL27260617 | 0.85 | KCNH2 (0.47) | MAP3K7TAB1BRD4LOXL2TTK | |
| SCHEMBL30765195 | 0.84 | MAP3K7 (0.37) | LMNAGAAHPGDHSD17B10KDM4E | |
| SCHEMBL30765350 | 0.84 | PIK3CD (0.41) | IRAK4GAAALDH1A1IRAK1BRD4 | |
| SCHEMBL27260725 | 0.84 | KCNH2 (0.40) | IRAK4IRAK1MAP3K7TAB1BRD4 | |
| SCHEMBL30765338 | 0.81 | RET (0.45) | IRAK1 | |
| SCHEMBL724751 | 0.81 | MAP3K7 (0.47) | IRAK1MAP3K7TAB1BRD4LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |