Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 4/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260978 | 1.00 | MAP3K7 (0.39) | MAP3K7TAB1ROCK2MTORPIK3CB | |
| SCHEMBL27260891 | 0.84 | MAP3K7 (0.38) | MAP3K7TAB1ROCK2PDE10A | |
| SCHEMBL30765195 | 0.82 | MAP3K7 (0.37) | MAP3K7TAB1ROCK2MTORPIK3CB | |
| SCHEMBL30765354 | 0.81 | FGFR3 (0.36) | MTORGABRA1PDE10A | |
| SCHEMBL27261209 | 0.81 | FGFR3 (0.36) | MTORGABRA1PDE10A | |
| SCHEMBL27260619 | 0.78 | NR1H2 (0.41) | MAP3K7TAB1MTORPIK3CBATR | |
| SCHEMBL30765258 | 0.78 | GABRA1 (0.35) | ROCK2GABRA1PDE10A | |
| SCHEMBL27260720 | 0.76 | MTOR (0.42) | MAP3K7TAB1MTORPIK3CBPRKDC | |
| SCHEMBL27260617 | 0.76 | KCNH2 (0.47) | MAP3K7TAB1ACVR1NR1H2NR1H3 | |
| SCHEMBL30765359 | 0.75 | HSD17B10 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |