Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | BRD2 | P25440 | 2/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.40 |
| ▸ | TYK2 | P29597 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260526 | 0.86 | PDE4C (0.43) | PDE4CKDM4EALDH1A1HPGDCA1 | |
| SCHEMBL30765218 | 0.86 | PDE4C (0.43) | PDE4CKDM4EALDH1A1HPGDCA1 | |
| SCHEMBL722404 | 0.85 | PDE4C (0.46) | PDE4CKDM4EHPGDCA1CA2 | |
| SCHEMBL722179 | 0.84 | CA1 (0.58) | PDE4CKDM4EHPGDCA1CA2 | |
| SCHEMBL722188 | 0.83 | PDE4C (0.44) | PDE4CKDM4EALDH1A1HPGDCA1 | |
| SCHEMBL27260528 | 0.80 | PDE4C (0.42) | PDE4CKDM4EALDH1A1HPGDCA1 | |
| SCHEMBL30765409 | 0.80 | SMN1; SMN2 (0.44) | BRD4KDM4EALDH1A1HPGDHTT | |
| SCHEMBL16638609 | 0.78 | PDE4C (0.50) | PDE4CKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL722839 | 0.78 | PDE4C (0.51) | BRD4PDE4CKDM4EALDH1A1HPGD | |
| SCHEMBL723093 | 0.77 | PDE4C (0.55) | BRD4PDE4CKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |