Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.73 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464351 | 0.84 | EPHX2 (1.00) | EPHX2GAAMAPK1KDM1AMAOB | |
| SCHEMBL25330218 | 0.81 | EPHX2 (0.46) | EPHX2MAPK1HDAC8 | |
| SCHEMBL30560749 | 0.80 | EPHX2 (0.47) | EPHX2BUB1GAARAB9ANFKB1 | |
| SCHEMBL464347 | 0.80 | EPHX2 (0.70) | EPHX2GAAMAPK1KDM1AMAOB | |
| SCHEMBL8276160 | 0.80 | EPHX2 (0.47) | EPHX2BUB1GAARAB9ANFKB1 | |
| SCHEMBL3287288 | 0.80 | EPHX2 (0.70) | EPHX2GAAMAPK1KDM1AMAOB | |
| SCHEMBL20803979 | 0.78 | EPHX2 (0.80) | EPHX2BUB1GAAMAPK1KDM1A | |
| SCHEMBL461147 | 0.77 | EPHX2 (0.65) | EPHX2MAPK1KDM4DHDAC8 | |
| SCHEMBL12894150 | 0.77 | EPHX2 (0.65) | EPHX2JAK1JAK2GAAMAPK1 | |
| SCHEMBL24096619 | 0.77 | EPHX2 (0.65) | EPHX2GAAKDM1AMAOBHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025856-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | CISTIM LEUVEN VZW (BE) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025856-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | YAP1, TEAD2, TEAD1 | EPHX2 2674/4885BUB1 1341/4885JAK1 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.